Applications of Acridine and Gallic Acid Noha Abdel Maksoud Hemaid1, Omnia Ibrahim Abdel Hack Al- Shabrawy1, Mohamed Mohamed Ahmed2, Mabrouk Attia Abd Eldaim1 1Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Menoufia

Abstract

Acridine is one of the simple alkaloids found in nature, has three fused rings with a nitrogen atom on the middle ring. Acridines are heteroaromatic compounds, which interact with both nucleic acids and proteins. The targeting of these biopolymers is broadly applied in cancer therapy and gene delivery. Interestingly, due to direct interactions of acridines with various enzymes, acridines can be suitable drugs for treatment of neurodegenerative diseases, inflammation, immunological disorders, protozoal diseases, diabetes, etc. Numerous processes, including reductive alkylation, nucleophilic addition, electrophilic substitution, reduction, oxidation, and photoalkylation, occur with arylidene.Gallic acid (GA) is a very rich in many edible and herbal plants and has an antioxidative and anti-inflammatory effects on some metabolic disorders. To have a better understanding of its antidiabetic properties and its therapeutic important on human health care, the available review supporting the effective properties of GA. This review outlined the uses of acridine and Gallic acid for treatment of different diseases.