article · Natural Product Research
Researchers isolated two novel lipids, lentinoside A and lentinamide A, from the fungus Lentinus sajor-caju, alongside four known compounds: stearic acid, ergosterol, ergosterol endoperoxide, and asperglaucide. These compounds and the fungal extract were evaluated for their antioxidant properties using DPPH radical scavenging, ABTS radical cation scavenging, and Ferric Reducing Antioxidant Power (FRAP) assays. Ergosterol endoperoxide and the fungal extract showed DPPH radical scavenging capacity, though less than ascorbic acid. Asperglaucide demonstrated the strongest ABTS activity, followed by lentinoside A and lentinamide A. Lentinamide A exhibited the highest ferric reducing capacity in the FRAP assay. These findings highlight the contribution of lipids and peptides to the nutraceutical potential of L. sajor-caju and expand the chemical diversity of bioactive fungal metabolites.
This research identifies new natural compounds with antioxidant properties from a common fungus. Antioxidants are important for health, as they can help protect cells from damage. Discovering new sources of these compounds could lead to novel ingredients for health-promoting products.
The identified compounds, particularly the novel lipids and asperglaucide, show potential as natural antioxidant ingredients. These could be of interest to the nutraceutical, functional food, or cosmetic industries for developing new products. This is early-stage research focused on identifying and characterising bioactive compounds through in vitro assays.
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Two novel lipids lentinoside A (6), [1-O-β-D-galactopyranosyl-(2S,3R,4E,8E)-2-[(2′R)-2-hydroxytricosanoylamino]-9-methyl-4,8-heptadecadiene-1,3-diol], and lentinamide A (5), [((2′R)-2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyheptatriacontan-2-yl)pentadecanamide)] were isolated from Lentinus sajor-caju (Fr.) Fr. 1838, alongside stearic acid (1), ergosterol (2), ergosterol endoperoxide (3), and asperglaucide (4). Antioxidant evaluation revealed that (3) (25.706%) and the extract (25.858%, IC50 = 0.188 mg/mL) exhibited DPPH• radical scavenging capacity, though lower than the reference ascorbic acid (21.26%, IC50 = 0.0621 mg/mL). In the ABTS•+ assay, (4) demonstrated the strongest activity (0.800 mg TE/g), followed by (6) (0.646 mg TE/g) and (5) (0.612 mg TE/g). FRAP assay revealed (5) had the highest ferric reducing capacity (0.982 ± 0.069 mg Fe(II)/g), followed by (4) (0.690 mg Fe(II)/g). In contrast, (2) (0.456 mg Fe(II)/g) and the extract (0.440 mg Fe(II)/g) displayed weak capacity. These findings highlight lipid and peptide contributions to the nutraceutical potential of L. sajor-caju and expands the chemical diversity of bioactive fungal metabolites.
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DOI: 10.1080/14786419.2026.2710831
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