article · Frontiers in Pharmacology

Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity

Manel Azzi
Ali Tliba
Ifriqya Medila
David Cornu
Salah Eddine Laouini
Abderrhmane Bouafia
Mikhaël Bechelany
Ibtissam Laib
Huda Alsaeedi
Ahmed Barhoum

202427 citationsOpen accessHelwan University

Abstract

Ag/Ag₂O NPs synthesized via green methods using olive leaf extract effectively mitigated metribuzin-induced toxicity, especially at lower doses, by improving oxidative stress markers and hematological and biochemical profiles. Dose optimization is crucial to maximize therapeutic benefits and minimize adverse effects, underscoring their potential in treating chemical-induced toxicity.

Research topics

Moringa oleifera research and applications
Nanoparticles: synthesis and applications
Nigella sativa pharmacological applications

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DOI: 10.3389/fphar.2024.1485525

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