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article · Journal of Natural Products

Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of <i>Dalbergia gloveri</i>

20248 citationsOpen accessUniversity of Nairobi

Abstract

Three new dihydroflavonols, gloverinols A-C (<b>1</b>-<b>3</b>), a new flavon-3-ol, gloverinol D (<b>4</b>), two new isoflavans, gloveriflavan A (<b>5</b>) and B (<b>6</b>), and seven known compounds were isolated from the root bark of <i>Dalbergia gloveri</i>. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (<b>2</b>), gloveriflavan B (<b>6</b>), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (<b>10</b>) were the most active against <i>Staphylococcus aureus</i>, with MIC values of 9.2, 18.4, and 14.2 μM, respectively.

Research topics

  • Bioactive natural compounds
  • Natural product bioactivities and synthesis
  • Phytochemistry and Biological Activities

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DOI: 10.1021/acs.jnatprod.4c00690

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