article · Asian Pacific Journal of Tropical Biomedicine
Chronic administration of the butanol fraction derived from Moringa stenopetala leaf ethanol extract demonstrates notable antidiabetic effects in alloxan-induced diabetic mice. Daily treatment across a 28-day period significantly lowered fasting blood glucose levels in treated mice compared to untreated diabetic controls. Alongside the reduction in blood sugar, the treatment produced significant decreases in both serum total cholesterol and triglyceride levels, while also showing a tendency to improve body weight gain in the diabetic subjects. Toxicity assessments revealed an oral median lethal dose exceeding 5000 milligrams per kilogram, indicating a high margin of acute safety in mice. While the physiological response suggests an action mechanism similar to that of sulfonylurea drugs, the specific active compounds driving these therapeutic outcomes remain to be identified and confirmed through further investigation.
Diabetes management frequently requires effective therapies that control blood sugar while managing related lipid complications. Demonstrating that leaf extracts from Moringa stenopetala reduce glucose, total cholesterol, and triglycerides in animal models supports the investigation of botanical sources for diabetes management. Because the extract showed low acute toxicity in mice, it highlights a potential natural basis for developing safer therapeutic options.
This work could eventually enable the development of plant-derived antidiabetic therapeutics or complementary treatments for managing blood sugar and lipid profiles. The potential end users are pharmaceutical developers and patients managing diabetes. However, this research is at an early pre-clinical stage in mice. Extensive further work is necessary to isolate the active chemical constituents, verify the precise mechanism of action, and evaluate human safety and efficacy before any commercial product can be realised.
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Abstract Objective The present study was conducted to evaluate the antihyperglycemic activity on chronic administration of the butanol fraction of the ethanol extract of Moringa Stenopetala leaves in alloxan induced diabetic mice. Methods The mice were grouped in four groups; Normal control, Diabetic control, Butanol fraction treated and standard drug treated groups. The Diabetic mice received the butanol fraction of Moringa stenopetala daily for 28 days. Results The butanol fraction of Moringa stenopetala treatment resulted in significant reduction of fasting blood glucose level, serum total cholesterol and triglycerides level. This fraction also showed a tendency to improve body weight gain in diabetic mice. Its oral LD50 was found to be greater than 5000mg/Kg indicating its safety in mice. Conclusions Though the mechanism of action of Moringa stenopetala seems to be similar to that of sulfonylureas, further studies should be done to confirm its mechanism of antidiabetic action. Furthermore the active principle(s) responsible for the antidabetic effects should also be identified.
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DOI: 10.1016/s2221-1691(12)60461-4
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