article · Planta Medica
We report the chemistry and anticancer activities of three African Croton species, C. mubango Mull. Arg., C. haumanianus J. Leonard and C. dictyophlebodes Radcl. -Sm. Forty-five previously undescribed diterpenoids and thirty known compounds were isolated from these species. NMR, MS, ECD, and DP4+ methods were used to determine the structures. Thirty diterpenoids were submitted to the NCI's Development Therapeutics Programme for testing in the NCI 60 anticancer cell line screening programme. Compounds 1 – 5 ([Fig. 1]) exhibited 100% lethality against colon (HCT-116), melanoma (M14), and renal (786 – 0) cancer cell lines whereas compound 6 gave 99%, 89% and 82% cell lethality against melanoma (MALME-3M), renal (UO-31) and ovarian (IGROV1) cancer cell lines respectively at a concentration of 10 – 5 M [1], [2], [3].
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DOI: 10.1055/s-0042-1759135
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