An overview of synthetic approaches and the potential bioactivity of different 1,2,3-triazole hybrids

Abstract

1,2,3-Triazole is considered to be the lead structure for the discovery of many drug molecules. 1,2,3-Triazole has received considerable attention in the field of drug discovery due to its remarkable widespread biological potential. This work summarizes the current synthetic pathways adopted for the synthesis of diverse analogs of 1,2,3-triazole. It also introduces an overview of the latest advances in 1,2,3-triazole hybrid models with various pharmacological activities, their chemical structures, structure–activity relationships, and mechanisms of action.