article · Advances in Biochemistry
Introduction:<i> Eribroma oblongum</i> (Malvaceae) (EO) stem bark is also used in traditional medicine to treat cardiovascular diseases and painful menstruation. This study aimed to estimate the mineral composition, <i>in vitro</i> antioxidant properties, and Interleukin-17 (IL-17) expression levels of hydroethanolic extract (EOHE) and the powder fraction ˂ 125µm (EOP) of <i>Eribroma oblongum</i> (EO), in Wistar rats with atherogenic diet-induced steatotic liver. Materials and methods: The mineral composition of these therapeutic plants was characterized through atomic absorption spectrometry. Antioxidant activities were measured using spectroscopic methods. Rats were given daily doses of EOP, EOHE (100mg/kg), or Atorvastatin (10mg/kg) as a positive control for 45 days at the same time as being fed an atherogenic diet. At the end of the treatment period, animals were sacrificed and liver and blood were collected for evaluation of biochemical parameters. The serum levels of cytokines IL-17 were measured by ELISA. Results: The results showed that EOP had a significantly <I>P˂0.0001</I> higher composition of Iron (25.75±0.6464g/100g DM), Zinc (11.71±7164g/100g DM), Vitamin C (41.60 ± 4.864g/100g DM), Manganese (2.02±0.0164g/100g DM), Selenium (0.037±0.000764g/100g DM) than EOHE. EOHE had a significantly higher polyphenol content (<i>p<0.05</i>) than EOP 917.33±23.63µg CaE/g DM. EOP and EOHE had good polyphenol contents (in descending order EOHE (995.43±24.10 (µg CaE/g DM)) > EOP(917.33±23.63 (µg CaE/g DM)). DPPH, FRAP, and TAC increased positively with hydroethanolic extract and powder concentration. EOP significantly (<I>P˂0.0001</I>) reduced IL-17 expression by 48,76% compared with the negative control group. Conclusion: These results demonstrated that EOP can be a source of anti-inflammatory agents in the fight against metabolic diseases. The therapeutic potential of <i>Eribroma oblongum</i> for the treatment of steatosis could be considered in further studies.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.11648/j.ab.20241201.12
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
