article · Physiological Genomics

Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunction

Heba Faheem
Abdallah Atef Homouda
Muhammad Tarek Abdel Ghafar
Alaa Elkordy
Radwa Ismail
Amira M. Elshamy
Fatma H. Rizk
Howayda E. Khaled
Eman Basha
Monira A. Seleem
Hoda Ibrahim
Reham A. aboeida
Shaimaa M. Motawea
Rana Alawadhi
Yasmeen M. El-Harty

20249 citationsOpen accessSuez University

Abstract

Celastrol inhibits the production of proinflammatory cytokines in the testicular tissue by specifically targeting the TLR4/MyD88/NF- κB signaling cascade pathways. This indicates that celastrol may serve as a promising new therapeutic target for treating diabetic reproductive dysfunction.

Research topics

Pregnancy and preeclampsia studies
Reproductive System and Pregnancy
Natural Compounds in Disease Treatment

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1152/physiolgenomics.00072.2024

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