preprint
<title>Abstract</title> Cognition, plasma brain derived neurotrophic (BDNF) levels and indices of inflammation were determined in 88 adults sub-divided into 4 groups; Group I (30–39 years), Group II (40–49 years), Group III (50–59 years) and Group IV (≥ 60 years) using standard procedures. There was a significant progressive reduction in cognitive score and plasma BDNF levels as the decades of life increased. The neurocognitive scores were significantly higher in Groups I, II and III than in Group IV. Similarly, the median plasma BDNF level was significantly higher in Group I than in Groups III and IV. Regression analysis revealed that age was negatively related to cognition (R<sup>2</sup> = 0.522, p = 0.000) and BDNF levels (R<sup>2</sup> = 0.095, p = 0.003). Plasma BDNF levels and cognitive scores progressively decrease with increasing age hence, plasma BDNF levels could predict susceptibility to neurocognitive dysfunction as aging progresses.
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DOI: 10.21203/rs.3.rs-5194167/v1
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