article · Natural Product Research

African mesquite elicits neuroprotective activity against quaternary metal mixture -induced olfactory bulb-hippocampal oxido-inflammatory stress via nrf2-hmox-1pathway

Orish Ebere Orisakwe
Ana Ćirović
Chinna N. Orish
Anthonet N. Ezejiofor
Evelyn Utomoibor Ikpeama
Harrison Anezi Ozoani
Aleksandar Ćirović
Kenneth O. Okolo
Ify L. Nwaogazie

2024Enugu State University of Science and Technology

Abstract

(10 mg/kg), for 60 days. Groups 3, 4, and 5 were treated with HMM along with AM at doses of 500, 1000, and 1500 mg/kg, respectively. AM decreased the Cd, As, Hg, and Pb levels in OB and HIP, restored the activities of antioxidants, Hmox-1, reduced the activities of AChE, NRF2 and NFkB and improved histopathology.

Research topics

Heavy Metal Exposure and Toxicity
Nanoparticles: synthesis and applications
Pharmacological Effects of Medicinal Plants

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DOI: 10.1080/14786419.2024.2381018

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