article · Natural Product Research
A previously undescribed bislabdane diterpenoid namely aframomumlabdane (<b>1</b>), was isolated from the seed of <i>Aframomum arundinaceum</i> together with seven known compounds (<b>2 </b>-<b> 8</b>). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound <b>1</b> was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1. The best activity was observed against SPC212 lung cancer cell line with an IC<sub>50</sub> value of 0.52 μM.
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DOI: 10.1080/14786419.2024.2372847
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