article · Trends in Parasitology
Gene drives could transform malaria control by enabling the rapid, autonomous spread of engineered traits in mosquito populations, potentially reducing dependence on costly interventions.African countries can adapt their existing vector surveillance systems to support future monitoring of gene-drive mosquitoes rather than building new infrastructure.They should prioritize actionable indicators with predefined thresholds tied to specific gene-drive mechanisms.For best results, they should integrate genetic, entomological, and health data, leveraging tools like PCR and artificial intelligence-enabled phenotyping for cost-effective tracking.Countries should also foster networks for transboundary surveillance, drawing from past precedents like the use of sterile insect technique.Modeling approaches can support adaptive sampling and optimize resource allocation in both field trials and implementation.
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DOI: 10.1016/j.pt.2026.03.010
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