Abnormal Glucose Tolerance Among Children with Cystic Fibrosis

Abstract

Abstract Background Cystic fibrosis (CF) is a severe, autosomal recessive disease of high prevalence caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene which is located on the long arm of chromosome 7. Objective to screen for glucose tolerance abnormalities among children with cystic fibrosis. Patients and Methods This was a cross-sectional study conducted on 25 cystic fibrosis patients in the age group from 1 – 15 years in the Pediatric pulmonology clinic, from the first of July 2020 to the end of January 2022. The patients were classified according to their glucose tolerance results into CF patients with normal glucose tolerance and CF patients with abnormal glucose tolerance. Results Our analysis also showed that the most important factor associated with abnormal glucose tolerance test was found to be higher age and glycosylated hemoglobin. The previous findings highlight the need for routine screening of CF patients to exclude CFRD or any abnormality in glucose tolerance in these patients. Conclusion The current study demonstrated that abnormal glucose tolerance is not uncommon among the studied CF patients. Our results concluded that abnormal glucose tolerance was significantly associated with older age and higher glycosylated hemoglobin.