A SHORT REVIEW ON CRYPTOSPORIDIUM AND COLONIC CANCER

Abstract

Cryptosporidium is one of the major causes of parasitic diarrhea all over the world. Both animalsand humans are impacted. The fecal-oral pathway encompasses the consumption of infected wateror food, as well as the intake of oocysts following direct touch with infected humans or animals.There is a lack of treatment alternatives for cryptosporidiosis sufferers. Nitazoxanide is theonly one that has been approved by the Food and Drug Administration (FDA) as a therapy forcryptosporidiosis. Colorectal cancers were linked to Cryptosporidium infections. Some diseases,including hematological malignancies and liver cancer were also be linked to infections withCryptosporidium spp. Infection with Cryptosporidium leads to hyperproliferation, invasion, andresistance to apoptosis and immune responses, via influencing host cellular pathways. While theexact processes that lead to Cryptosporidium-induced intestinal neoplasia remain a mystery, it isevident that they are complex and involve both the parasite and the host. Cancer is the leadingcause of death and disability is colon cancer.