A review: Imidazole and its biological activities

Abstract

Imidazole is a planner heterocyclic five-member ring with 3C and 2N atom and in ring N is present in 1st and 3rd positions. The imidazole ring is a constituent of many important natural products, including purine, histidine, and nucleic acid. Being polar and ionizable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus used as a drug to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. Derivatives of Imidazole have occupied a critical place in the field of medicinal chemistry. imidazole nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the imidazole related drugs have improved the medicinal chemists to synthesize enormous number of novel chemotherapeutic agents. Methods for the synthesis of imidazole and their various structure reactions offer enormous scope in the field of medicinal chemistry. This article seeks to review the work reported, their chemistry and biological activities of imidazole during past years.