article · British Journal of Clinical Pharmacology

A randomized controlled study of neoadjuvant metformin with chemotherapy in nondiabetic breast cancer women: The METNEO study

Manar A. Serageldin
Noha A. El‐Bassiouny
Rania G. Aly
Yasser Elkerm
Mahmoud M. El‐Mas
Maged W. Helmy
Amira B. Kassem

20246 citationsOpen accessDamanhour University

Abstract

Metformin improves clinical and pathological responses to neoadjuvant AC-T chemotherapy in BC via prompting directionally opposite changes in DRs (increments) and CD133 + (decrements) expressions. This study was registered in ClinicalTrials.gov (registration number: NCT04170465, https://clinicaltrials.gov/ct2/show/NCT04170465).

Research topics

Metabolism, Diabetes, and Cancer
Cancer Cells and Metastasis
Cancer-related Molecular Pathways

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1111/bcp.16193

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