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article · European Thyroid Journal

A post-irradiation-induced replication stress promotes RET proto-oncogene breakage

2024Open accessMohammed V University

Abstract

The findings suggest that post-irradiation in the RET gene causes a breakage in the replication fork, which could potentially invade another genomic area, including CCDC6. As a result, this could greatly contribute to the high prevalence of chromosomal RET/PTC rearrangements seen in patients exposed to external radiation.

Research topics

  • DNA Repair Mechanisms
  • Radiation Therapy and Dosimetry
  • Cancer-related Molecular Pathways

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DOI: 10.1530/etj-24-0028

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