article · European Journal of Medicinal Chemistry

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments

Salma M. Hefny
Ahmed M. El‐Dessouki
Tarek F. El‐Moselhy
Andrea Ammara
Claudiu T. Supuran
Ahmed A. Al‐Karmalawy
Galal Yahya
Nabaweya Sharaf El-Din
Moataz A. Shaldam
Marta Ferraroni
Andrea Angeli
Haytham O. Tawfik

202435 citationsOpen accessKafr el-Sheikh University

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Research topics

Enzyme function and inhibition
Synthesis and Catalytic Reactions
Coagulation, Bradykinin, Polyphosphates, and Angioedema

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DOI: 10.1016/j.ejmech.2024.116527

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