A New Clinical Approach to Manage The Increased Incidence of Dental Caries Associated With Diabetes Mellitus Using Pilocarpine Nanoparticles And an InsituGel as an Oral Drug Delivery System”

Abstract

Diabetes mellitus is one of the serious diseases with more prevalence in middle east and north Africa. The poor metabolic control associated with diabetes mellitus results in reduced salivary flow rates with remarkable increase in the incidence of dental caries. The aim of this study was to provide a new clinical approach for diabetic patients, during the initial periods of poor metabolic control, in order to decrease the incidence of demineralization and establishment of carious lesions. One hundred diagnosed type 2 diabetic patients were included in this study. They were devided into two groups of 50. Group B was the control group while group A represented the group of patients that underwent the clinical management using Pilocarpine and an insitu gel of carbapol and chitosan that acted as a local drug delivery system. DMFT scores , salivary flow rates and salivary pH measurements were obtained. The results showed that group A patients were significantly superior to the patients of group B in terms of the DMFT scores , salivary flow rates and salivary pH measurements.