A New Approach for Native Myocardial T1 mapping using a standard Single-shot MRI pulse sequence technique.

Abstract

Cardiovascular magnetic resonance (CMR) diagnosis of acute myocarditis (AM) requires contrast injection in Late Gadolinium Enhancement (LGE). Native T1- mapping has been suggested as a potentially helpful technique in connection to the quantitative assessment of cardiac anomalies. This was demonstrated utilizing particular sequences, which are manufacturer-specific and not practicable on all machines. In this study, we propose to evaluate the capability of a standard, single-shot sequence in the clinical context to distinguish between healthy myocardium and diffuse disease. For this, 30 patients (22 participants with no cardiac involvement and 8 patients with verified cardiac involvement based on echocardiographic criteria and Troponin levels) received CMR (3-T) with LGE imaging. This analysis revealed that cardiac T1 times were significantly higher in patients with myocarditis (1516± 29ms), myocardial infarction (1596± 98ms), and pericardial effusion (1217± 12ms) than in healthy subjects (1117± 15ms). Furthermore, in roughly 2 minutes, our model reconstruction allows for single-shot myocardial T1 maps with great spatial resolution, precision, accuracy, and consistency. As it underlined the importance of T1 mapping in clinical application improvement and its contribution to direct assessment of cardiac system anomalies