A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats

Abstract

An 11-week vitamin D/PTU-supplemented HFD induces an LDL-dominant dyslipidemia with systemic inflammation and evidence consistent with endothelial dysfunction, alongside histological features of early vascular remodeling and hepatic steatosis. This nongenetic model may be useful for studying early atherogenic changes.