A dataset of HLA-A allele sequences and periodontal disease status in people living with HIV

Abstract

OBJECTIVES: This dataset was generated to investigate the distribution of HLA-A alleles in people living with HIV (PLWH) with and without periodontitis in Uganda. The data were collected as part of the parent study Oral papillomavirus, microbiota and cancer in people living with HIV (OHPVMC). The dataset provides valuable information about host genetic factors that may influence periodontal disease susceptibility in HIV-positive populations. DATA DESCRIPTION: The dataset includes nanopore sequencing data (FASTQ format) for HLA-A alleles obtained from 64 PLWH participants (32 with periodontitis and 32 without). It also contains accompanying clinical metadata including periodontitis severity scores, age, sex, antiretroviral therapy duration, number of drinks per day and number of cigarettes per day. Processed files include HLA-A allele calls in CSV format, and file linking the barcodes to the unique identification numbers. All data files have been deposited in public repositories to facilitate reuse in immunogenetics and oral health research. The raw sequencing data are available through NCBI's Sequence Read Archive, while processed data and metadata are hosted on Figshare. This dataset will be particularly valuable for researchers studying genetic susceptibility to oral diseases, HLA diversity in African populations, and the application of nanopore sequencing for HLA typing.