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article · Mendeleev Communications

A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones

Abstract

An expedient access to novel 4-phosphonomethyl-containing 2,6-disubstituted 4,5-dihydropyridazin-3(2 H )-ones involves the reaction of β-phosphono γ'-keto ester intermediates with hydrazines. The construction of the pyridazinone ring allows the installation of various substituents at the positions 2 and 6 as well as a valuable 4-positioned phosphonomethyl fragment.

Research topics

  • Synthesis and Reactivity of Heterocycles
  • Synthesis and Biological Evaluation
  • Chemical Synthesis and Analysis

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DOI: 10.1016/j.mencom.2023.09.016

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