583 Comparative Outcomes of One Anastomosis Gastric Bypass and Sleeve Gastrectomy: A Retrospective Analysis of Weight Loss and Micronutrient Deficiencies in Superobese Patients at 12 Months

Abstract

Abstract Aim This study aimed to compare the efficacy of one-anastomosis gastric bypass (OAGB) and sleeve gastrectomy (SG) in achieving weight loss and evaluating postoperative micronutrient disturbances in super-obese patients. Method A single-center retrospective cohort study was conducted using medical records of patients with a body mass index (BMI) ≥50 kg/m² who underwent either OAGB or SG. Results A total of 92 patients were included in the analysis, with 53 undergoing SG and 39 undergoing OAGB. Baseline characteristics were comparable between the groups, except SG patients were significantly younger, and SG surgeries had shorter durations (30 vs. 53 minutes). Patients in the OAGB group had a higher prevalence of co-morbidities such as diabetes mellitus, hypertension, and ischemic heart disease. No significant differences were observed between the two groups in terms of hospital stay length or postoperative complications. Both procedures resulted in significant weight loss at 3, 6, and 12 months postoperatively. While weight loss at 3 and 6 months was comparable, OAGB demonstrated significantly greater weight loss at 12 months (p=0.03). However, micronutrient analyses showed significantly better postoperative levels of zinc, hemoglobin, ferritin, total iron-binding capacity (TIBC), iron, and vitamin B12 in the SG group compared to the OAGB group. Conclusions OAGB achieved greater long-term weight loss than SG in super-obese patients but was associated with a higher risk of micronutrient deficiencies, particularly in iron, vitamin B12, and zinc. SG may be a preferable option for patients at higher risk of nutritional deficiencies.