245P Age-adjusted trends of pulmonary large cell neuroendocrine carcinoma

Abstract

Pulmonary large cell neuroendocrine carcinoma is a rare high grade lung cancer. It shows mixed features of both small cell and non-small cell lung cancer which explains the poor prognosis it carries. Due to its scarcity, there are limited data regarding incidence rates and trends and in turn, lead to underdeveloped understanding of its pattern and guidelines for screening and treating it. Data of 11029 patients from the Surveillance, Epidemiological, and End Results (SEER) database diagnosed from 2000-2020. We analyzed age-adjusted trends and age adjusted incidence rates. Rates are per 100,000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) standard; confidence intervals are 95% for rates (Tiwari mod) and trends. Percent changes were calculated using 1 year for each end point; APCs were calculated using weighted least squares method. The 5-year relative survival was 20.8%. The overall incidence was 0.36. The age adjusted trends showed a percent change (PC) of 2,474.23 with an annual percent change (APC) of 1.66 (95% CI 0.11 to 3.24). This increase was among all ages, races, and sexes. With stratification by sex, from year 2000 to 2020, males showed higher incidence rates per year compared to females with rates of 0.40 and 0.26, respectively, in 2020. Males also demonstrated higher PC of 3203.49 while for females it was 1,887.60. Females showed slightly larger APC of 1.58 (95% CI -0.04 to 3.19) compared to males; 1.56 (95%CI 0.01 to 3.18). Pulmonary large cell neuroendocrine carcinoma showed poor overall survival. It showed an overall increase in its incidence rate. Males showed higher incidence rate than females however, females showed slightly more increase in their incidence rate compared to males. This increase in the incidence rate combined with poor survival outcomes of pulmonary large cell neuroendocrine carcinoma warrants the development of screening guidelines. We recommend focusing on males as they have the highest incidence rate.