21P Age-adjusted trends in patients with head and neck sarcomas

Abstract

Head and neck sarcomas are rare however, they tend to be aggressive and carry poor prognosis. We have limited data regarding their trends due to this scarcity which in turn lead to poorly developed screening and treatment guidelines. So, we aim to analyze age-adjusted trends of head and neck sarcoma. We extracted the data of 9044 from the Surveillance, Epidemiological, and End Results (SEER) database diagnosed from 2000-2020. We analyzed Age-Adjusted Trends and Age-adjusted incidence rates. Rates are per 100,000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) standard; Confidence intervals are 95% for rates (Tiwari mod) and trends. Percent changes were calculated using 1 year for each end point; APCs were calculated using weighted least squares method. The overall incidence rate is 30%. The age-adjusted trend analysis showed a Percent change (PC) of 18.9 and an annual percent change (APC) of 1.3 (95%CI: 0.8 to 1.8). With stratification by sex, males showed higher PC and APC; PC:24.6, APC:1.4 (95%CI: 0.9 to 2.0) compared to females; PC:3.2, APC:0.6 (95%CI: -0.1 to 1.4). We also analyzed age-adjusted trends based on age groups; 0-19, 20-39, 40-59, and 60+. They showed PCs of -7.1, -3.2, -14.0, 46.7 respectively and APCs of 0 (95%CI: -1.1 to 1.2), 0.4 (95%CI -0.5 to 1.4), 0.4 (95%CI -0.7 to 1.5), and 1.9 (95%CI 1.3 to 2.5) respectively. Head and neck sarcomas showed an overall high incidence rate. It also demonstrated a rising incidence rate throughout the years. Both Males and females showed an increase with more predominance by males. Only age group 60+ had a rising incidence rate, while the rest of age groups had a declining incidence rate. The poor prognosis combined with high incidence rate of head and neck sarcoma warrants the need to develop screening guidelines to combat this rise. We recommend more focus on males and aged 60+ as they showed the most increase.